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KMID : 0380020130280050269
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Korean Journal of Biotechnology and Bioengineering
2013 Volume.28 No. 5 p.269 ~ p.274
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Motor Neuron Disease and Stem Cell Approach for Its Remediation
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Kim Jong-Deog
Bhardwaj Jyoti
Chaudhary Narendra
Seo Hyo-Jin
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Abstract
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Motor neuron disease (MND) is a fatal neurodegenerative disorder caused by progressive and selective degeneration of motor neurons (MNs). Because of the versatile nature, stem cells have the potential to repair or replace the degenerated cells. In this review, we discussed stem cell based therapies including the use of embryonic stem cells (ESCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs) and genetically engineered cells to produce the neurotrophic factors for the treatment of MND. To achieve this goal, the knowledge of specificity of the cell target, homing and special markers are required.
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KEYWORD
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Embryonic stem cells, Induced pluripotent stem cells, Motor neuron diseases, Neural stem cells, Superoxide dismutase
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